Endocrine Abstracts

Introduction: Simultaneous pancreas-kidney transplantation (SPKT) is the best way to restore normoglycemia and renal function in patients with type 1 diabetes mellitus (T1D) and end-stage renal disease (ESRD). Pregnant patients after SPKT are a high-risk group for adverse events/loss fetal and transplantation organs. These risks are significantly reduced due to pregnancy planning, regular monitoring of the woman and fetus condition with timely correction of immunosuppressive t...

Introduction: Today simultaneous pancreas-kidney transplantation (SPKT) is an effective method of treatment for patients with type 1 diabetes mellitus (T1D) and terminal stage of diabetic nephropathy (DN) on renal replacement therapy by hemodialysis. It solves several problems: reduces the severity of intoxication syndrome, contributes to the achievement of euglycemia in most cases, that allows to delay progression of micro- and macrovascular diabetic complications. Case Descr...

Objectives: to study the response of calcium and phosphate homeostasis parameters to the cholecalciferol loading dose in patients with predialysis chronic kidney disease (CKD). Methods: We examined 17 patients with stage 3 CKD (CKD3) and 9 patients with stages 4–5 CKD (CKD4-5) without previously known disorders of mineral metabolism and intake of interfering drugs during last 3 months. The assessments included serum 25-hydroxyvitamin D (25(OH)D), free 25...